Enantioselective total synthesis of marine diterpenoid clavulactone.
نویسندگان
چکیده
The key steps in the synthesis of clavulactone are formation of an enantiopure cyclopentane precursor by epoxide rearrangement and intramolecular carbonyl-ene reaction, construction of the 3,4-dihydro-2H-pyran ring by intermolecular hetero-Diels-Alder reaction, closure of the eleven-membered ring, and finally generation of the lactone functionality by chemoselective allylic C(sp(3))-H oxidation.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 51 26 شماره
صفحات -
تاریخ انتشار 2012